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发表于 2010-11-1 20:51:16
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文献六:Mitochondrial DNA footprints in modern Mongolian(译作现代蒙古人群的(母系遗传)线粒体DND印记), 2008
2008年美国人类基因学年会上的一篇文献,此文献采集了约3000个蒙古样本,包含了21个部落和族裔群体,结果表明有40%的西欧亚成分,而最多的H约7%,此文献的西欧亚血统成分大大多于之前的采样,可能与西部小部族的样本数量比较多有关。遗憾的是,此文献迟迟未见相关学术杂志公开发表。 Abstract Information
Poster Board Number: 2582/T Presentation Time: Thu, Nov 13, 2008, 4:30PM-6:30PM
Keywords: Evolutionary and Population Genetics, KW140 - POPULATION GENETICS, KW057 - EVOLUTIONARY GENETICS, KW112 - MITOCHONDRIA, KW141 - POPULATION STRUCTURE, KW084 - HAPLOTYPE
Abstract Content
Mitochondrial DNA footprints in modern Mongolia. S. R. Woodward1, A. Achilli2,3, U. A. Perego1,3, J. E. Gomez-Palmieri1, D. Tumen4, E. Myagmar4, D. Bayarlhagva4, K. H. Ritchie1, A. Pollock1, N. Angerhofer1, A. Torroni3, N. M. Myres1, Sorenson Molecular Genealogy Foundation, SLC, UT (USA) 1) Sorenson Molecular Genealogy Foundation, Salt Lake City, UT, USA; 2) Dip. di Biologia Cellulare e Ambientale, Università di Perugia, Perugia, Italy; 3) Dip. di Genetica e Microbiologia, Università di Pavia, Pavia, Italy; 4) National University of Mongolia, Ulan Bator, Mongolia.
Although Mongolia is one of the most sparsely populated countries in the world, it is located at a pivotal crossroad between the four corners of Asia (including the well-known “Silk Road”) and has been characterized throughout history by events that greatly added to its current cultural and ethnic diversity. Among these, perhaps one of the most significant happening was the ambitious expansion strategy employed by Mongolia’s most prominent personality, Genghis Khan, whose empire eventually stretched across all of modern-day China, a portion of modern Russia, Southern Asia, Eastern Europe and the Middle East. In 2007, through a well-planned collection effort, researchers at the Sorenson Molecular Genealogy Foundation and the National University of Mongolia were able to gather over 3,000 DNA samples, informed consents, and genealogical data throughout the country of Mongolia, including samples from 21 distinct tribal or ethnic populations. All the samples were sequenced for the three hypervariable segments of the mitochondrial DNA (mtDNA) control region to assess the genetic composition of modern Mongolia. The most common mtDNA haplotypes are typical of haplogroup C, which is frequent throughout Eastern Asia. However, nearly 40% of the observed mtDNA lineages are of Western Eurasian origin, including a significant frequency (~7%) of haplogroup H - the most common in Europe. The high prevalence of Western Eurasian lineages could be a remnant from Genghis Khan’s conquering efforts, trade and cultural exchanges along the Silk Route. To assess the extent of recent gene flow that could account for the elevated levels of Eurasian haplogroups within Mongolian populations, we have examined genealogical data of samples representative of Western Eurasian haplogroups.
这篇文献掉人胃口的地方在于:
1)采集了3000+例样本,这个太疯狂了,大家要知道,目前发表的数据大多,就是几十例而已。
2)高达40%的西欧亚母系单倍体型,光西欧亚的H就达7%,这有点不可思议,要知道虽然蒙古人含一部分西欧亚血统并没有什么惊讶,但以往采样大多不超过10%,好家伙,这个一下子就飙到40%的西欧亚混血,这对我们传统认识的冲击实在够大。
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